Editorial - Post-COVID: Together, we will do better

The Battle Against COVID-19: Where Do We Stand Now?

We must--and we can--do better.

Editorial We Can Do It Together: PAR1/PAR2 Heterodimer Signaling in VSMCs

In this issue, Sevigny and colleagues demonstrate that a protease-activated receptor (PAR)1–PAR2 heterodimer regulates vascular smooth muscle cell (VSMC) hyperplasia following vascular injury.1 PARs belong to a family of G-protein coupled receptors that are proteolytically activated by a variety of proteases.2,3 Cleavage of PARs results in intracellular signaling mediated by activation of vario...

Libet Do We Have Free Will ?

I have taken an experimental approach to this question. Freely voluntary acts are preceded by a specific electrical change in the brain (the ‘readiness potential’, RP) that begins 550 ms before the act. Human subjects became aware of intention to act 350–400 ms after RP starts, but 200 ms. before the motor act. The volitional process is therefore initiated unconsciously. But the conscious funct...

Commentary: Circulating cytokines and risk stratification of stroke incidence--will we do better in future?

tory markers and onset of cardiovascular events: results from the Health ABC study. Circulation 2003;108: 2317–22. 37 Sacco RL. Risk factors for TIA and TIA as a risk factor for stroke. Neurology 2004;62 (8 Suppl 6):S7–11. 38 Kuller LH. Epidemiology and prevention of stroke, now and in the future. Epidemiol Rev 2000;22:14–17. 39 Reynolds K, Lewis LB, Nolen JDL, Kinney GL, Sathya B, He J. Alcoho...